pentobarbital will lessen the extent or impact of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; prevent use in sufferers who are chronically working with a powerful CYP3A4 inducerNext oral or parenteral administration, barbit